Biomedical Engineering | Materials Science & Engineering

Featured Publication

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Surface-Initiated Assembly of Protein Nanofabrics
Feinberg AW and Parker KK. Nano Letters, 2010.

Featured Image

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Endothelial cells on patterned micro-stars of fibronectin alter their cytoskeleton in response to the engineered surface (red = actin; blue = nucleus; green = fibronectin)

Tissue Engineering

• Fabrication of cardiomyocyte anisotropic 2D tissues with uniaxial, synchronized contraction
  
• Use of thermally sensitive polymers to release micropatterned cells from substrates
  
• Micropatterned neural networks
  

Optical Tweezers

• Design and fabrication of high resolution particle tracking hardware and software solution
  
• Tracking of actin motile beads and actin motile bacteria at 1 nm steps
  

Atomic Force Microscopy

• Biochemically functionalized AFM probes for mapping the location and quantifying the binding force of receptors on the surface of live cells
  
• Topography and mechanical properties of live and fixed tissues such as artery and brain
  
• AFM based nanolithography, especially for adding nanopatterns to micropatterned surfaces
  

Microengineered Surfaces

• Design and fabrication of microtopographies specifically for enhancing or inhibiting cell adhesion
• Microcontact printing for tissue engineering endothelial cell monolayers on elastomers
  
• Combining microtopography and microcontact printed chemistry on the same surface
  
• Hierarchical topography combining micrometer and nanometer scale surface features
  

Microfluidics

• Method to chemically functionalize PDMSe with antibodies to target specific cell populations
  
• Device design and fabrication to separate circulation endothelial cells from blood
  
• Device design to separated platelets from blood